Feraheme
(Ferumoxytol)
Provider Summary
Primary Uses
Iron deficiency anemia in adults who have intolerance to oral iron or have chronic kidney disease and meet criteria.
Mechanism of action
IV iron (superparamagnetic iron oxide) that replenishes iron stores for hemoglobin synthesis.
Pre-treatment / baseline requirements
Baseline CBC, iron studies (ferritin, transferrin saturation), assess prior reactions to IV iron; pregnancy status when appropriate; monitor vitals during and after administration.
Common side effects
Hypotension, nausea, dizziness, headache, injection site reactions.
Serious adverse effects / key risks
Hypersensitivity including anaphylaxis; clinically significant hypotension; iron overload with excessive dosing.
Referral requirements
Standard infusion referral form + drug-specific checklist
Imaging note
Ferumoxytol may affect MRI studies for several weeks to months after administration; advise radiology if MRI is planned soon after dosing.
Patient & Caregiver Education
What it treats
Iron deficiency anemia in adults who have intolerance to oral iron or have chronic kidney disease and meet criteria.
How it works
Replaces iron through an IV to help rebuild iron stores and hemoglobin.
Before treatment
Tell your clinician if you have an active infection/fever, are pregnant/planning pregnancy, or have major heart/nerve problems. Depending on the medication, you may need labs or screening tests (e.g., TB/hepatitis) and a vaccine review.
Common side effects
Hypotension, nausea, dizziness, headache, injection site reactions.
Get urgent help for
Hypersensitivity including anaphylaxis; clinically significant hypotension; iron overload with excessive dosing.
On treatment day
Plan to stay for monitoring. If you feel dizzy, drowsy, or unwell afterward, do not drive and follow your clinician’s instructions.