Vyepti
(Eptinezumab)

Provider Summary

Primary Uses

Preventive treatment of migraine in adults

Mechanism of action

Monoclonal antibody targeting CGRP ligand, reducing migraine signaling.

Pre-treatment / baseline requirements

Review migraine diagnosis and prior preventive failures; screen for hypersensitivity history; pregnancy status when applicable.

Common side effects

Nasopharyngitis, hypersensitivity-related symptoms.

Serious adverse effects / key risks

Hypersensitivity including anaphylaxis (rare).

Referral requirements

Standard infusion referral form + drug-specific checklist

vyepti (eptinezumab)

Patient & Caregiver Education

What it treats

Preventive treatment of migraine in adults

How it works

Blocks CGRP signaling to help prevent migraines.

Before treatment

Tell your clinician if you have an active infection/fever, are pregnant/planning pregnancy, or have major heart/nerve problems. Depending on the medication, you may need labs or screening tests (e.g., TB/hepatitis) and a vaccine review.

Common side effects

Nasopharyngitis, hypersensitivity-related symptoms.

Get urgent help for

Hypersensitivity including anaphylaxis.

On treatment day

Plan to stay for monitoring. If you feel dizzy, drowsy, or unwell afterward, do not drive and follow your clinician’s instructions.