Nucala

(mepolizumab)

Provider Summary

Primary Uses

Severe eosinophilic asthma (add-on maintenance) and other eosinophilic disorders per labeled indications and payer criteria.

Mechanism of Action

Anti‑IL‑5 monoclonal antibody reduces eosinophil levels.

Pre-treatment / Baseline Requirement

Confirm eosinophilic phenotype/indication; treat helminth infections when applicable; vaccination review.

Common side effects

Headache, injection-site reactions, back pain, fatigue; herpes zoster has been reported.

Serious adverse effects / key risks

Hypersensitivity reactions; serious infections (rare).

Referral requirements

Standard infusion referral form + drug-specific checklist

Nucala

Patient & Caregiver Education

What it treats

Severe eosinophilic asthma and other eosinophilic disorders per labeled indications and payer criteria.

How it works

Anti‑IL‑5 monoclonal antibody reduces eosinophil levels.

Before treatment

Tell your clinician if you have an active infection/fever, are pregnant/planning pregnancy, or have major heart/nerve problems. Depending on the medication, you may need labs or screening tests (e.g., TB/hepatitis) and a vaccine review.

Common side effects

Headache, injection-site reactions, back pain, fatigue; herpes zoster has been reported.

Get urgent help for:

Hypersensitivity reactions; serious infections.

On treatment Day:

Plan to stay for monitoring. If you feel dizzy, drowsy, or unwell afterward, do not drive and follow your clinician’s instructions.