Provider Summary
Primary Uses
Add-on maintenance treatment of severe asthma (and CRSwNP per label) in patients meeting criteria.
Mechanism of Action
Monoclonal antibody targeting thymic stromal lymphopoietin (TSLP), upstream of multiple inflammatory pathways.
Pre-treatment / Baseline Requirement
Confirm severe asthma phenotype and inadequate control; screen for hypersensitivity history; treat helminth infection when applicable; vaccination review.
Common side effects
Pharyngitis, arthralgia, back pain, nasopharyngitis; injection-site reactions.
Serious adverse effects / key risks
Hypersensitivity reactions (can be delayed).
Clinical notes
Patients will have reduced opioid analgesic response while on naltrexone; emergency analgesia planning is important.
Referral requirements
Standard infusion referral form + drug-specific checklist
Patient & Caregiver Education
What it treats
Add-on maintenance treatment of severe asthma (and CRSwNP)
How it works
Monoclonal antibody targeting thymic stromal lymphopoietin, upstream of multiple inflammatory pathways.
Before treatment
Tell your clinician if you have an active infection/fever, are pregnant/planning pregnancy, or have major heart/nerve problems. Depending on the medication, you may need labs or screening tests (e.g., TB/hepatitis) and a vaccine review.
Common side effects
Pharyngitis, arthralgia, back pain, nasopharyngitis; injection-site reactions.
Get urgent help for:
Hypersensitivity reactions.
On treatment Day:
Plan to stay for monitoring. If you feel dizzy, drowsy, or unwell afterward, do not drive and follow your clinician’s instructions.