Provider Summary
Primary Uses
Rheumatoid arthritis, psoriatic arthritis, and other indications per label/payer criteria.
Mechanism of Action
Selective T-cell costimulation modulator (CTLA‑4 Ig) blocks CD80/86–CD28 interaction, reducing T-cell activation.
Pre-treatment / Baseline Requirement
Screen for active infection; TB screening is commonly performed; baseline CBC/CMP per clinician; vaccination review.
Common side effects
Headache, upper respiratory infections, nausea, infusion reactions (IV).
Serious adverse effects / key risks
Serious infections; hypersensitivity; COPD exacerbations have been reported in some populations.
Referral requirements
Standard infusion referral form + drug-specific checklist
Patient & Caregiver Education
What it treats
Rheumatoid arthritis, psoriatic arthritis, and other indications
How it works
Selective T-cell costimulation modulator blocks CD80/86–CD28 interaction, reducing T-cell activation.
Before treatment
Tell your clinician if you have an active infection/fever, are pregnant/planning pregnancy, or have major heart/nerve problems. Depending on the medication, you may need labs or screening tests (e.g., TB/hepatitis) and a vaccine review.
Common side effects
Headache, upper respiratory infections, nausea, infusion reactions.
Get urgent help for:
Serious infections; hypersensitivity; COPD exacerbations have been reported in some populations.
On treatment Day:
Plan to stay for monitoring. If you feel dizzy, drowsy, or unwell afterward, do not drive and follow your clinician’s instructions.