Reclast
(Zoledronic Acid)
Provider Summary
Primary Uses
Osteoporosis and other bone disease indications per label/payer criteria.
Mechanism of action
Bisphosphonate inhibits osteoclast-mediated bone resorption.
Pre-treatment / baseline requirements
Renal function (SCr/eGFR) prior to each dose; baseline calcium/vitamin D; dental evaluation for ONJ risk; ensure hydration; avoid in significant renal impairment per PI.
Common side effects
Acute phase reaction (fever, myalgias), headache, arthralgia.
Serious adverse effects / key risks
Renal toxicity; hypocalcemia; osteonecrosis of the jaw; atypical femur fracture.
Referral requirements
Standard infusion referral form + drug-specific checklist
Patient & Caregiver Education
What it treats
Osteoporosis and other bone disease indications
How it works
Bisphosphonate inhibits osteoclast-mediated bone resorption.
Before treatment
Tell your clinician if you have an active infection/fever, are pregnant/planning pregnancy, or have major heart/nerve problems. Depending on the medication, you may need labs or screening tests (e.g., TB/hepatitis) and a vaccine review.
Common side effects
Acute phase reaction, headache, arthralgia.
Get urgent help for
Renal toxicity; hypocalcemia; osteonecrosis of the jaw; atypical femur fracture.
On treatment day
Plan to stay for monitoring. If you feel dizzy, drowsy, or unwell afterward, do not drive and follow your clinician’s instructions.