Vyvgart
(Efgartigimod)
Provider Summary
Primary Uses
Generalized myasthenia gravis (AChR+) and other indications depending on product labeling.
Mechanism of action
FcRn antagonist → lowers circulating IgG.
Pre-treatment / baseline requirements
Infections; infusion/injection-related reactionsConfirm diagnosis/antibody status; screen for active infection; review vaccination status; baseline labs per clinician.
Common side effects
Respiratory tract infection, headache, urinary tract infection.
Serious adverse effects / key risks
Serious infections; hypersensitivity; infusion reactions (IV product).
Referral requirements
Standard infusion referral form + drug-specific checklist
Patient & Caregiver Education
What it treats
Generalized myasthenia gravis and other indications depending on product labeling.
How it works
Lowers certain antibodies (IgG) by blocking the FcRn pathway.
Before treatment
Tell your clinician if you have an active infection/fever, are pregnant/planning pregnancy, or have major heart/nerve problems. Depending on the medication, you may need labs or screening tests (e.g., TB/hepatitis) and a vaccine review.
Common side effects
Respiratory tract infection, headache, urinary tract infection.
Get urgent help for
Serious infections; hypersensitivity; infusion reactions.
On treatment day
Plan to stay for monitoring. If you feel dizzy, drowsy, or unwell afterward, do not drive and follow your clinician’s instructions.